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In the world of GLP-1 receptor agonists, semaglutide has become a key player for several health conditions. But with growing patient demand and evolving regulations, healthcare providers are looking beyond traditional injections to explore new ways to deliver this powerful therapy.

One of the most promising alternatives? Sublingual administration.

Why Sublingual Semaglutide?

This method is quick, efficient, and requires no injections. Sublingual dosing provides an alternative administration route, enabling direct absorption into the bloodstream via the mucosal tissue, thus avoiding the gastrointestinal tract and first-pass metabolism. This approach can enhance bioavailability and make treatment more accessible for patients who have difficulty with injections.

Best Practices for Sublingual Administration

Sublingual therapy requires more than just placing the medication under the tongue and swallowing. To enhance absorption, it is crucial for the medication to remain in contact with the sublingual or buccal tissue for an extended period.

The minimum recommended hold time is 30 seconds, but patients should strive for 5 to 15 minutes. Longer contact with the sublingual tissue can improve absorption, while swallowing the compounded preparation may lead to minimal absorption.

Tips for Better Absorption:

• Take the dose on an empty stomach or away from meals to minimize salivation and swallowing.
• Avoid eating or drinking for at least 15–30 minutes after dosing.
• Try holding the dose while reading, watching TV or during quiet moments to extend the hold time.

Newburgh – Ruffian Ln

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